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Mississippi River Cruises aboard Queen of the Mississippi

Queen of the Mississippi paddlewheel river boat cruises

Beneath Queen of the Mississippi's gleaming woodwork and polished brass is a framework of modern technology that provides passengers the most enjoyable Mississippi River cruise imaginable as our all-American crew delivers the personalized service that is the hallmark of American Cruise Lines.

Mississippi River Cruise Itineraries:

Click Summary Cruise Information below for detailed cruise information


Lower Mississippi River Cruise

from New Orleans, LA or Memphis, TN

 Lower Mississippi River cruise from New Orleans to Memphis  This Lower Mississippi River cruise is a perfect getaway for the music enthusiast, history buff, and food aficionado in each of us. Join us this 8-day voyage from New Orleans to Memphis as we discover the historic and culturally rich ports of Natchez, Vicksburg and Oak Alley, LA.  

Cruise Highlights: New Orleans, Oak Alley, Baton Rouge, St. Francisville, Natchez, Helena, and Memphis

Mississippi River Cruises New Orleans

Mississippi River Paddlewheel Cruise

New Orleans, LA

Mississippi River boat cruise form New Orleans, LA

Explore the iconic cities of New Orleans, Baton Rouge and Oak Alley, LA on this 8-day, round-trip paddlewheel cruise from New Orleans, LA.

Discover the history of “the Big Easy”, the romance of Natchez, or pay tribute to the blue and gray at Vicksburg National Military Park.

Enjoy legendary Southern hospitality for yourself with guided shore excursions and fine regional cuisine prepared by highly acclaimed chefs.

Cruise Highlights: New Orleans, Natchez, Vicksburg, St. Francisville, Baton Rouge, and Oak Alley, LA

New Orleans River Cruises

Upper Mississippi River Cruise

from St. Louis, MO or St. Paul, MN

Mississippi River cruise from St. Louis to Memphis

Cruise the upper Mississippi River on an 8-day voyage from St. Louis to St. Paul aboard the stunning, new Queen of the Mississippi paddlewheeler.

From tranquil towns and bustling cities to impressive locks and dams, adventure is around every corner. Pilot a river barge at the Dubuque’s Mississippi River Museum, dance to Scandinavian folk tunes at the Norwegian Heritage Center in La Crosse, or explore the heart of Amish Country.

Cruise Highlights: St. Louis, Alton, Hannibal, Burlington, Davenport, Dubuque, La Crosse, Winona, Red Wing, and St. Paul

St. Louis Mississippi River Boat Cruises


Mississippi and Ohio River Cruise

from St. Louis or Cincinnati, OH

 Mississippi Riverboat Cruises from St. Louis to Cincinnati

Cruise the Mississippi and Ohio Rivers from St Louis to Cincinnati, OH aboard the Queen of the Mississippi. Beneath this incredible paddlewheeler’s gleaming brass is a framework of modern technology that provides spacious accommodations and the most comfortable cruising experience imaginable. 

Join us as we explore the historic ports of St. Louis, Louisville, and Mount Vernon on this 8 day paddlewheel cruise.

Cruise Highlights: St. Louis, Paducah, Cave in Rock, Henderson, Mt. Vernon, Louisville, Madison, and Cincinnati

 Mississippi River Boat Cruises St. Louis to Cincinnati


Mississippi Paddlewheel Riverboat Cruise

from Memphis, TN to St. Louis, MO

Cruise the Mississippi River from Memphis to St. Louis

Step back in time and enjoy the rhythm of the Mississippi River aboard an 8-day cruise from Memphis, TN to St. Louis, MO. From the great Gateway Arch, the country’s tallest man-made monument, to the exciting city of Memphis, famous for its blues, barbeque, and Graceland, you’ll travel a little slower.

Between these two great cities you’ll cruise on the Mississippi River and explore Civil War and Underground Railroad sites, visit the most haunted city in America, and discover quintessential small-town America.

Cruise Highlights: St. Louis, Alton, Cape Girardeau, Paducah, Columbus, New Madrid, Tunica, and Memphis

Memphis to St. Louis Riverboat Cruises
Free Shore Excursions
on Mississippi River Cruises
Reserved Today!

to reserve your stateroom*

2014 American Cruises Lines Brochure


Mississippi River Cruise Map

Cruise the length of the Mississippi and Cumberland Rivers from New Orleans, St. Louis and many other ports.

Mississippi River Cruise Map

(click to enlarge cruise map)


*Free shore excursions only on new 2014 Mississippi River cruise bookings. Ship, cruise, itinerary, and complimentary excursions are subject to change at any time. Call a cruise specialist at 1-800-460-4518 for more information on terms and conditions of this special offer.