Call a Cruise Specialist 1.800.460.4518
7 days a week*
Cruise the Mississippi River Aboard Three New Paddlewheelers
New Orleans Round-Trip Cruise
Upper Mississippi River Cruise
Memphis to Nashville Cruise
Cumberland River Cruise
Grand Heartland cruise
New Orleans, LA to Memphis, TN
Cruise the land bayous and Southern Belles on an 8-day, round-trip cruise from New Orleans, LA. Explore New Orleans, Oak Alley, Natchez, Vicksburg, St. Francisville, Baton Rouge and Houmas House as you travel in relaxed comfort with American Cruise Lines.
Experience legendary Southern hospitality with guided shore excursions and fine regional cuisine prepared by highly acclaimed chefs.
St. Louis, MO to St. Paul, MN
Cruising the upper Mississippi River from St. Louis to St. Paul is filled with changing landscapes and cultural influences.
From tranquil towns and bustling cities to impressive locks and dams, adventure is around every corner. Visit St. Louis, Alton, Hannibal, Burlington, Davenport, Dubuque, La Crosse, Winona, Red Wing, and St. Paul.
Cruise the Mississippi and Ohio Rivers from St Louis to Cincinnati, OH aboard the Queen of the Mississippi. Beneath this incredible paddlewheeler’s gleaming brass is a framework of modern technology that provides spacious accommodations and the most comfortable cruising experience imaginable.
Join us as we explore the historic ports of St. Louis, Paducah, Cave in Rock, Henderson, Mt. Vernon, Louisville, Madison, and Cincinnati.
Mark Twain cruises
Civil War cruises
Independence Day cruise
Fall Foliage cruises
New Year's Cruise
Captivating Shore Excursions
Historic Oak Alley Plantation
National Military Park in Vicksburg
Mark Twain's Home in Hannibal
Enjoy a brief history of the Mississippi River and it's unique place in American history, music and culture. Read more...
*Cruise specialists are available to take your calls at 1.800.460.4518
8:30am to 8:30pm Eastern Time (5:30pm Pacific Time)
© Copyright 2015 American Cruise Lines. All rights reserved.