St. Louis - Cincinnati Cruise

Eight-Day / Seven-Night Ohio River Cruise
Departing from St. Louis, MO or Cincinnati, OH

Experience the picturesque waterways of the Mississippi and Ohio Rivers aboard the magnificent Queen of the Mississippi. Step back in time to the grand era of paddlewheels as we explore the heartland of America. While the churn of the paddlewheel blends with the sounds of the river, you’ll rediscover the America of the pioneers, the America of boundless optimism and unlimited possibilities.

Cruise from St. Louis, MO or Cincinnati, OH with stops at the River Heritage Museum in Paducah, Cave-in-Rock State Park, and Churchill Downs in Louisville, KY. Click the Day by Day tab for details.

Request a Free Brochure or call 1-800-460-4518
 for additional cruise details.

Click on Images Above to View Photo Gallery
St. Louis - Cincinnati  Cruise Map  This incredible journey from St. Louis  to Cincinnati includes enchanting ports like Cave-In-Rock, Madison, and other beautiful Northern destinations.

To see more about this Mississippi River voyage, click the blue Day by Day tab above.

Day 1
St. Louis, MO

Gateway Arch St. Louis

Reflect upon the role St. Louis played in the opening of the American frontier as you cruise past the famed Gateway Arch Riverfront, the tallest manmade monument in the U.S. Get settled in at a festive cocktail event with a welcome from the captain as you prepare for a trip down the Mississippi to the Ohio River, one of the most picturesque waterways in the country.

Day 2
Cape Girardeau, MO

Small Ship Cruising on the Ohio River

In 1773, French soldier Jean Baptiste de Giradot established a trading post in what is now known as Cape Giradeau. After the Seven Years War, settlement of the city began in earnest in 1793. Shared by Spain, local Indian tribes and American settlers, Cape Giradeau was finally incorporated as an official town in 1808. Site of the Battle of Cape Giradeau in 1863, this historic site was a vital port for traders traversing the Mississippi River. Tours of Cape Giradeau include visits to many captivating landmarks including the Mississippi River Tales Mural, Riverfront Park and the Confederate War Memorial. 

Day 3
Paducah, KY

Buildings Downtown Paducah

Located at the confluence of the Tennessee River and the Ohio River, Paducah will have you feeling as if you stepped back in time as you walk the streets of this Chicasaw village site. Discover Paducah’s rich history by exploring the Wall to Wall mural program, a collection of over 50 murals that covers a number of subjects including Native American history, the Civil War and area landmarks such as the old Carnegie Library.

Day 4
Henderson, KY

John James Audubon Museum

You won’t miss the presence of notable resident naturalist, John James Audubon, whose “Birds of America” paintings are recreated in bronze statues located throughout Henderson. Named after Washington’s home on the Potomac - this bucolic river town is steeped in fascinating lore. A private guide will take you through our famous first president’s home and grounds. From there, you can choose to visit numerous historic sites such as Posey County Courthouse Square, Downtown Historic District, and the William Gonnermann House.

Day 5
Louisville, KY

Louisville Slugger Museum

Whether you’re a fan of horse racing or not, you know why Louisville is a popular destination for travelers. Named after King Louis XVI of France, Louisville is best known for the famed Kentucky Derby, the first leg of the Triple Crown of Thoroughbred Racing. When you visit, you’ll also discover why Louisville is often referred to as either the northernmost Southern city or the southernmost Northern city in the United States, with prevalent influences from both Southern and Midwestern culture.

Day 6
Madison, IN

Family on Madison Trolley

This once-bustling river port, known as the “19th-century Williamsburg of America,” is a veritable treasure trove of historic places and intriguing Federal and Greek Revival-style architecture. Be sure to tour the historic workplace of the Schroeder Saddletree Factory and Museum. Perhaps you’ll also catch the powerboat racing regatta, an annual event and tradition dating back to 1911.

Day 7
Day of River Cruising

Mississippi River

Grab a good book and curl up in one of our spacious lounges as the Queen of the Mississippi makes its way down the Ohio River. Bird watchers and nature enthusiasts will find the Queen of the Mississippi's top deck to be the ideal location to identify different species of birds and other wildlife that call the Ohio River home.

Day 8
Cincinnati, OH

Harriet Tubman

As you disembark in Cincinnati, take some time to visit the numerous National Historic Sites via walking tours through Cincinnati’s oldest neighborhoods filled with eclectic architecture. Visit the William Howard Taft National Historic Museum, the National Underground Railroad Freedom Center and Betts House.

Mississippi River Cruises on Queen of the Mississippi

Beneath the gleaming woodwork and brass fixtures aboard Queen of the Mississippi is a framework of modern cruise ship technology that provides passengers with the most comfortable vacation imaginable as we cruise the Mississippi and Ohio Rivers from New Orleans to Minneapolis or Cincinnati, OH.  The Queen of the Mississippi features the most spacious staterooms in the industry and provides more space per passenger than any other river cruise ship.Click play to see more.

Date # of Nights Cruise Departure Location Ship
Jul 18, 2015 7 St. Louis - Cincinnati Cruise St. Louis, MO Queen of the Mississippi
Jul 25, 2015 7 St. Louis - Cincinnati Cruise Cincinnati, OH Queen of the Mississippi
Jul 9, 2016 7 St. Louis - Cincinnati Cruise Cincinnati, OH Queen of the Mississippi

QofMSR Thumbnail

Queen of the Mississippi

Queen of the Mississippi delivers an experience unlike any other riverboat. Launched in 2012 and modeled after traditional Victorian-style riverboats of the late 1800s, she was the first paddlewheeler built for the Mississippi River in nearly 20 years. Queen of the Mississippi offers passengers modern amenities and comforts including large staterooms with private balconies, hotel-style bathrooms, complimentary room service, WiFi, and more. Transporting guests back in time in the most elegant fashion, the experience aboard Queen of the Mississippi is a seamless blend of old and new. Beneath her historic décor, gleaming woodwork and brass fixtures is a framework of modern cruise ship technology that provides passengers with the most comfortable and upscale vacation imaginable on the Mississippi River.
Rate Schedule Per Person A AAR AAL AAC Owner's Suite Single w/ Balcony Single
7 Nights $4,450 $5,200 $5,760 $5,905 $7,410 $6,610 $6,010

Rates subject to change

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