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Mississippi River Cruises

US River Cruises

Cruise the Mississippi River Aboard Two Paddlewheelers

Mississippi River cruises with American Cruise Lines are an exceptional way to discover American history and culture as you travel the Mississippi, Ohio and Cumberland Rivers. Enjoy luxurious accommodations and finely-tailored, personal service aboard either of two paddlewheel riverboats, America and Queen of the Mississippi, built specifically for Mississippi River cruising. Cruise from New Orleans, Memphis, Nashville, and St. Paul and more with a variety of one, two and three week itineraries.

Lower Mississippi River Cruise

New Orleans, LA to Memphis, TN

Mississippi River cruises: New Orleans to Memphis
Cruise the lower Mississippi River aboard a paddlewheeler as we explore the culture, music, history and cuisine of this intriguing part of the deep South.

Your 8-day journey begins in either New Orleans or Memphis and features stops in Oak Alley, Baton Rouge, St. Francisville, Natchez, and Vicksburg. 

Enjoy guided shore excursions at each port including a tour of the Oak Alley Plantation, the Louisiana State Capital in Baton Rouge and National Military Park in Vicksburg.

Lower Mississippi River cruise

New Orleans Round-Trip Cruise

New Orleans Round Trip Cruise Map

Cruise the land of bayous and Southern Belles on an 8-day, round-trip cruise from New Orleans, LA.  

Explore New Orleans, Oak Alley, Natchez, Vicksburg, St. Francisville, Baton Rouge and Houmas House as you travel in relaxed comfort aboard a Mississippi paddlewheeler.

Experience legendary Southern hospitality with guided shore excursions and finest regional cuisine prepared by our highly acclaimed chefs.

New Orleans round trip cruises

Upper Mississippi River Cruise

St. Louis, MO to St. Paul, MN

St. Louis - St. Paul Cruise Map


Cruising the upper Mississippi River from St. Louis to St. Paul features ever-changing landscapes and cultural influences that can't be found anywhere else. 

From tranquil towns and bustling cities to impressive locks and dams, adventure is around every corner. Enjoy visits to St. Louis, Hannibal, Davenport, Dubuque, La Crosse, Red Wing, and St. Paul.

Take part in guided shore excursions including a visit to the boyhood home of Mark Twain in Hannibal and a historic city tour of Dubuque.

Upper Mississippi River cruises


Ohio River Cruise

Memphis, TN to Cincinnati, OH

US River Cruises


Cruise the Mississippi and Ohio Rivers from Memphis to Cincinnati, OH aboard the Queen of the Mississippi. Beneath this incredible paddlewheeler’s gleaming brass is a framework of modern technology that provides spacious accommodations and the most comfortable cruising experience imaginable. 

Join us as we explore the historic ports of Memphis, New Madrid, Paducah, Henderson, Louisville, Madison and Cincinnati. 

Ohio River cruises


Queen of the Mississippi Virtual Tour

Captivating Shore Excursions

Oak Alley Plantation
Historic Oak Alley Plantation

National Military Park in Vicksburg, MS
National Military Park in Vicksburg

Mark Twain boyhood home in Hanibal, MO on Mississippi Cruise shore excursions
Mark Twain's Home in Hannibal

Recent Awards

River Cruises

River Cruising


River Cruises