Florida and Southeast United States Cruises

Cruise the Florida Coast

Florida and the southeastern region of the United States offer a unique blend of history and natural beauty. Early explorers found sanctuary in the bountiful lands of this region, and it was in these safe waters that the American ideal was born. Discover the charm of the Old South and cruise along the Intracoastal Waterway during one of our six southeast U.S. cruises. Each of these cruises will take you to the best that each area has to offer and will allow you to connect with like-minded travelers. Our all American crew will attend to your every need, ensuring the ultimate cruise experience.

Historic South & Golden Isles Cruise

Eight-Day / Seven-Night Cruise
Departing from Charleston, SC or Jacksonville, FL

South and Golden Isles Cruise from Charleston or Jacksonville

To cruise the Intracoastal Waterway is to take a trip through American history. Cruise from Charleston or Jacksoville and visit the gems of the South: Charleston, Savannah, and Hilton Head. From the American Revolution to true Southern culture, you will discover it all on this cruise through the South.

Ports of Call: Charleston, Savannah, Beaufort, Jekyll Island, St. Simons Island, Sapelo Island, Amelia Island, Jacksonville

Chesapeake Bay Cruise

Eight-Day / Seven-Night Cruise
Departing from Baltimore, MD

Cruise the Chesapeake Bay from Batlimore

Sail the Chesapeake Bay to the Historic Triangle – Jamestown, Yorktown, and Williamsburg, and truly experience the origins of America. Continue onward to visit Annapolis and tour the U.S Naval Academy, or wander along its brick streets filled with unique shops and galleries.

Port of Call: Baltimore, Williamsburg, Yorktown, Jamestown, Tangier Island, Crisfield, Solomons Island, Cambridge, Oxford, St. Michaels, and Annapolis

Great Rivers of Florida Cruise

Eight-Day / Seven-Night Cruise
Departing from Jacksonville, FL

Discover the pristine splendor and unspoiled treasures of Florida’s St. Johns River. This eight-day cruise will bring you into the heart of Ocala National Forest, where you will encounter fascinating wildlife and verdant river banks. Spend an evening anchored in Lake George, tour the Ravine Gardens State Park, and experience the quaint charm of historic St. Augustine on this profound journey.

Ports of Call: Jacksonville, Palatka, Ocala National Forest/Lake George, Green Cove Springs, St. Augustine, and Amelia Island

East Coast Inland Passage Cruise

Fifteen-Day / Fourteen-Night Cruise
Departing from Baltimore, MD or Jacksonville, FL

East Coast River Cruises from Baltimore or Jacksonville

For the guest wanting the complete southern experience, this fifteen-day cruise is just for you. You will be exposed to the best areas the east coast has to offer. Explore the unique and quaint towns of Norfolk and Wilmington. Take in the magnificence of historic Charleston and experience the exquisite grace and charm of Savannah. Conclude your cruise by discovering the beauty of St. Simons, Jekyll, and Amelia Islands.

Ports of Call: Norfolk, Kitty Hawk, Oriental, Morehead City, Wilmington, Myrtle Beach, Beaufort, Hilton Head Island, Savannah, St. Simons Island, Jekyll Island, Sapelo Island

Mid-Atlantic Inland Passage

Eight-Day / Seven-Night Cruise
Departing from Baltimore, MD or Charleston, SC

From the galleries and museums in historic Norfolk, to the casual, yet delightful ambience of Myrtle Beach, this cruise will expose you to the best of the Intracoastal Waterway. Explore the charming harbor towns of Beaufort, Kitty Hawk, and Morehead City, kayak or canoe in picturesque Oriental, and tour the historic riverfront of Wilmington, all while enjoying the personal touch of American Cruise Lines.

Ports of Call: Baltimore, Norfolk, Kitty Hawk, Oriental, Morehead City, Beaufort, Wilmington, Myrtle Beach, Charleston

Potomac and Tidewaters Cruise

Eight-Day / Seven-Night Cruise
Departing from Philadelphia, PA or Washington, D.C.

This cruise takes you down the Chesapeake Bay on a journey through the cities and towns which helped shape the United States. From Annapolis to Mount Vernon, from St. Michaels to Chestertown, this cruise will not only expose you to the glorious history of the nation, but also the intriguing past of seafaring history and tradition.

Ports of Call: Washington D.C., Mount Vernon, St. Mary's, Annapolis, St. Michaels, Chestertown, Harve de Grace, and Philadelphia

"Thanks for a memorable trip. I love the Chesapeake more than ever."
Veranne A., San Antonio, TX, Chesapeake Bay Cruise
"Everything about the cruise was terrific. The staff couldn't have done a better job of making us happy."
Sue H., West Chester, PA, Great Rivers of Florida Cruise
"Traveling with American Cruise Lines is a wonderful experience with a crew of such caring, kind, and friendly people consistently working to give you an enjoyable trip."
Geraldine B., Schaumburg, IL, Potomac and Tidewaters Cruise
"The cruise was wonderful; the food was great; the crew was the best I've ever seen; our stateroom was comfortable and clean...all of our needs were met cheerfully and promptly!"
Charles T., Pearland, TX, East Coast Inland Passage Cruise